W-sh mice does not impair antibody-mediated arthritis
نویسندگان
چکیده
In a neutrophil-dependent arthritis elicited by injections of a mixture of anti – type II collagen mAbs followed by LPS, mice lacking the tyrosine-based inhibitory receptor leukocyte Iglike receptor B4 (LILRB4) have an exacerbated clinical response characterized morphologically by greater synovial thickening with neutrophil infi ltration and depletion of articular cartilage matrix with erosions, compared with Lilrb4 +
منابع مشابه
Mast cell deficiency in KitW-sh mice does not impair antibody-mediated arthritis
We previously reported that joint swelling, synovial thickening, and cartilage matrix depletion induced by the injection of anti-collagen monoclonal antibodies and lipopolysaccharide (LPS) in BALB/c mice are increased in the absence of inhibitory leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4; formerly gp49B1) in a neutrophil-dependent manner. Because both mast cells and neutrophils exp...
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